Endocrine Abstracts

Objective: An adrenal incidentaloma is discovered in about 3–4% of patients undergoing radiological examination (CT/MRI) of the abdominal region. Current diagnostic algorithms for differentiating between benign and malignant lesions largely depend on imaging studies, which lack in specificity. This often leads to extended radiological follow-up of benign lesions, which is time-consuming, expensive and carries a health risk. It was recently suggested that urinary steroid p...

Introduction: Carcinoma of the adrenal cortex (ACC) is a rare disease with an estimated incidence of 1–2 per 1 million population. Optimal treatment of ACC is multidisciplinary and has complex aspects such as adrenal surgery, adjuvant therapy with mitotane and cytotoxic chemotherapy in advanced stages. The Dutch Adrenal Network (DAN), a collaboration between all university centers and Máxima Medical Center, was founded with the objective of improving patient care and...

The finding of an adrenal incidentaloma warrants a careful diagnostic work-up to assess hormonal activity and potential malignancy. Current diagnostic algorithms depend largely on imaging studies, which is time-consuming, expensive and carries a health risk. Urinary steroid profiling using gas chromatography/mass spectrometry (GC/MS) might be a valuable diagnostic test for differentiating benign from malignant adrenal lesions, as adrenocortical carcinomas (ACC) often cause abn...

Introduction: The low incidence rate of adrenocortical carcinoma requires a multidisciplinary approach in which specialised surgery has an essential role as complete resection of the primary tumour is the only chance of cure.In order to improve patient care, insight into surgical results within the ACC population is essential. In 2007, a Dutch Adrenal Network Registry has been created encompassing care and outcome of patients treated for ACC in The Nethe...